EMPowerplus Methylated Advanced™

EMPowerplus Methylated Advanced™

Availability: In stock

EMPowerplus is the most studied micronutrient formula in the world, boasting over 30+ medical journal publications.

In our observations, we have found that EMPowerplus Methylated Advanced works best in those who have depression or are under-methylators.

Please be aware, we have found that taking a methylated product can cause hyper or over-methylation symptoms in those experiencing or have the symptoms of:

Autism, Bipolar I, Anxiety, Schizoaffective Disorder, OCD or ADHD

If you have any of the symptoms listed above, click here to order EMPowerplus Advanced. Or, if you have any questions, please call the support center at 1-888-878-3467 and we will assist you in picking the best product for your individual needs.


Empowerplus Methylated Advanced is our original and unique formulation of 36 nutrients, only differing in using the methylated forms of two vitamins, B12 and folate.

We created this formula for those whose bodies cannot methylate B vitamins as most can. Individuals that suffer with the rare MTHFR gene expression will benefit most from this product.

If you are uncertain that this methylated formula is right for you, please call and speak with a support representative that will help you with your choice of products.

The creators of EMPowerplus discovered that the cause of many mood disorders is usually related to nutrient deficiencies or an inability to extract vital nutrients from food. By adding EMPowerplus, the body is typically able to establish the right levels of vitamins and minerals required for proper brain function.

34 Research Studies

The EMPowerplus Formulation is the most research vitamin/mineral supplement in the world.

36 Ingredients

EMPowerplus Methylated Advanced provides a broad spectrum, highly absorbable range of nutrients that are essential to brain function.


We wrap the minerals in an organic molecule and bind them to proteins the body can easily recognize and digest.


Using cutting edge technology, minerals are pulverized to a size the body can use.

Balanced Nutrition

EMPowerplus Methylated Advanced is proportioned and balanced for maximum absorption and effectiveness.


Micronutrients in high enough doses to sufficiently address deficiencies and promote proper metabolic functioning.

**These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


While EMPowerplus Methylated Advanced™ is made up of all-natural, clinically proven ingredients it is important to consider that is should not be taken with any psychotropic medications or any addictive medications without first consulting with Truehope Support Staff.

The unique technology used in the micronutrient formulation of EMPowerplus Methylated Advanced™ is called Apex Biosynthesis Conversion Technology™. This allows the body to safely and rapidly absorb and use each of the 36 EMPowerplus Methylated Advanced™ essential elements for optimum physical and mental health. EMPowerplus Methylated Advanced™ is a safe, effective, all-natural formula for common mood disorders.

The majority of vitamin and mineral supplements found in supermarkets and health food stores cannot be easily digested due to the size of the particles and the improper ratios of certain minerals that depend on each other for full absorption. Many supplements also contain inferior chelates and low quality ingredients.

The unique formula and the advanced technology used to produce EMPowerplus Methylated Advanced™ address these common problems, making EMPowerplus Methylated Advanced™ the highest quality micronutrient formulation available on the market today.

  • Micronization
    • Using cutting edge technology, minerals are pulverized to a size the body can use. While most supplements are produced in 4 hours, the EMPowerplus Methylated Advanced™ micronization process takes up to 4 days.
  • Chelation
    • Minerals are difficult for the body to digest in pure form. To overcome this, EMPowerplus Methylated Advanced™ minerals go through a rigorous process that wraps them in organic molecules and binds them to proteins the body can easily recognize and digest.
  • Balance
    • Vitamins and minerals depend on each other for absorption in the body. For example, you need the right amount of zinc to absorb magnesium fully. Similarly, without vitamin D in balance, calcium cannot be readily absorbed. The micronutrients in EMPowerplus Methylated Advanced™ have been deliberately proportioned and balanced for maximum absorption and effectiveness.
  • Quantity
    • The average therapeutic dose of EMPowerplus Methylated Advanced™ is 4 capsules per day and provides a full spectrum of micronutrients in high enough doses to sufficiently address deficiencies and promote proper metabolic functioning.

Truehope has a high level of commitment to the quality of our products and to the quality of service we provide you.

Our products and those we work with must meet rigorous GMP(Good Manufacturing Practices) standards. Our manufacturing and packaging facility is registered with and inspected by the FDA and the Department of Health and Human Services. This, along with the dedication of our wonderful team of employees, is why you can depend on the quality, potency and purity of our products.

Click here to learn more about our Product Quality and Good Manufacturing Practices.



Supplement Facts

Serving size: 2 capsules
Servings per container: 60
Amount per serving% DV
Vitamin A (as retinyl palmitate) 230 mcg 26
Vitamin C (as ascorbic acid) 80 mg 89
Vitamin D (as cholecalciferol) 4.8 mcg (192 IU) 24
Vitamin E (as d-alpha tocopheryl succinate) 32 mg 213
Thiamin (as thiamin mononitrate) 2.4 mg 200
Riboflavin 1.8 mg 138
Niacin (as niacinamide) 12 mg 75
Vitamin B6 (as pyridoxine hydrochloride) 4.8 mg 282
Folate (as calcium L-R-MTHF) 326 mcg DFE 82
Vitamin B12 (as methylcobalamin) 120 mcg 5000
Biotin 144 mcg 480
Pantothenic acid (as d-calcium pantothenate) 2.8 mg 56
Calcium (as chelate) 176 mg 14
Iron (as chelate) 1.8 mg 10
Phosphorus (as chelate) 112 mg 9
Iodine (from atlantic kelp) 28 mcg 19
Magnesium (as chelate) 80 mg 19
Zinc (as chelate) 6.4 mg 58
Selenium (as chelate) 26 mcg 47
Copper (as chelate) 0.96 mg 104
Manganese (as chelate) 1.28 mg 56
Chromium (as chelate) 84 mcg 240
Molybdenum (as chelate) 20 mcg 44
Potassium (as chelate) 32 mg 1

Proprietary blend

[Choline bitartrate, DL-phenylalanine, vanadium chelate, lemon bioflavonoid complex 10% (from Citrus limon fruit), inositol, L-glutamine, L-methionine, boron chelate, grape seed extract, ginkgo leaf extract, germanium sesquioxide, nickel chelate]
335 mg **
** %Daily Value (%DV) not established.

Other ingredients: gelatin, glycine, microcrystalline cellulose, citric acid, magnesium stearate, mineral wax, turmeric root extract (color), silicon dioxide

Click here to download the ingredient list.


Customer Reviews 10 item(s)

Aynslie R. posted on 5/22/2021
Verified Purchase
This is an excellent nutritional supplement. I have been taking it for several years now.
Roslyn K. posted on 5/2/2021
Verified Purchase
I take this along with empowerplus regular because I have gut problems that interfere with absorbing nutrients. I think thiskeeps everything functioning well.
Herma posted on 3/27/2019
Verified Purchase
I can tell from my personal experience that this product gave me more energy and brain clarity. I feel all around better when I take it. Thank you True Hope for a wonderful product!
S Simpson posted on 3/23/2019
Verified Purchase
This product has helped me so much in my 40+ year battle with Clinical Depression! I have eliminated one RX and drastically reduced 2 other RXs! It is the best discovery l have ever made.
S. Bailey posted on 2/21/2019
Verified Purchase
I gave this product a 5 star rating because it lives up to all my expectations in a product. I suffered for 15 years with Bipolar Depression, being suicidal many times. I have been taking this product for 4 years and have not had more than one day of depression in that time. Also, the support staff at True Hope is remarkable at helping you through your transition to the product and afterward. I cannot say enough great things about this product and Truehope. Life changing product. Amazing customer service. I wish I could give it more stars.
Dr. Judy C. posted on 6/10/2021
Verified Purchase
I'm a holistic psychologist and regularly recommend this product to my clients. I've been taking empower for years and definitely find it helps me to handle stress and has sharpened my mind greatly.
Bethany L. posted on 10/28/2020
Verified Purchase
I struggled with anxiety and depression for years. I have tried medications, counseling, different techniques to calm down, and some of worked but none, NONE as good as these vitamins! I use to have panic attacks, and now it has been over a year since my last one. I can seriously tell the difference from when I am taking them and when I’m not. It’s a worlds difference! Then no withdrawals if you go off of them. There’s so many good things to say about these. I really didn’t think anything would be able to help me. Then I was told about True Hope and I’m very happy I was. I have recommended these to so many family and friends and have gotten to see how the vitamins helped them too! Highly recommended!
Ken S. posted on 3/20/2020
Verified Purchase
A couple of years ago my husband and I had the 23 and Me test. It told us that we didn't absorb our medicine and that we needed methylate to help. We were excited to see that Empowerplus came out with the methylated advanced so we tried it. We feel it has been a great source added to our diet. Our only problem is that it doesn't smell good; but we by pass that problem and take it everyday.
Dr. Taylor S. posted on 12/29/2019
Verified Purchase
Using this product for patients afflicted with various mental health issues has demonstrated consistent results for safety and improvement in symptoms.
Jacqueline J. posted on 6/6/2019
Verified Purchase
The methylated formulation works well for me. I suspect that I am a poor methylator so I feel this has greatly helped reduce anxiety and depression- I feel wonderful!

    Only registered users who purchased the product can write a review.